Get Emergency healthcare assistance When you've got signs of an allergic reaction to Xanax: hives; difficult breathing; swelling of your encounter, lips, tongue, or throat. Metabolism Alprazolam is thoroughly metabolized in individuals, principally by cytochrome P450 3A4 (CYP3A4), to 2 important active metabolites inside the plasma: four-hydroxyalprazolam and α-hydroxyalprazolam. The waiting for link from RSS